Based on a true story, SÉRAPHINE centers on Séraphine de Senlis, a simple and profoundly devout housekeeper whose brilliantly colorful canvases adorn some of the most famous galleries in the world. German art critic and collector Wilhelm Uhde - the first Picasso buyer and champion of naïve primitive painter Le Douanier Rousseau - discovers her paintings while she is working for him as a maid in the beautiful countryside of Senlis near Paris. A moving and unexpected relationship develops between the avant-garde art dealer and the visionary outsider artist.